Bionmie Rightest^TM Series Do Not Use GDH-PQQ, the Enzyme that FDA Issued a
Public Health Notification on Potentially Fatal Errors with Glucose Monitoring
Technology

August 19, 2009 -Bionime today announced that its Rightest^TM Series Blood Glucose
Monitoring Systems, DO NOT USE GDH-PQQ Technology. The FDA(Food and Drug
Administration) issued a Public Health Notification on Potentially Fatal Errors with GDH-PQQ
Glucose Monitoring Technology on August 13, 2009. The list of GDH-PQQ test stripsand
their associated meters is as below hyperlink.
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/PatientAlerts/ucm177189.
htm#attachment

It is important for you to know that Bionime Rightest^TM Series Blood Glucose Monitoring Systems, DO NOT USE GDH-PQQ Technology, and as such are not subject to the issues addressed by this FDA Notification. GOD, FAD-GDH, and GDH-PQQ are three common
enzymes that are used for the blood glucose meter. All of Bionime's Glucose
Monitoring Systems use GOD to develop the Patented Technology Test Strips.
The excellent test results of our series blood glucose monitoring system get a lot of
attentions from the well-known Journals, such as Analytical Chemistry, Clinical Chemistry,
Clinica Chimica Acta...etc.

In the recently issued Patient Alert, the FDA provides the following important information
for Diabetic Patients and/or caregivers regarding these serious errors with certain Blood
Glucose Monitoring Test Strips.

Advice
NEVER use GDH-PQQ* glucose meters or test strips if you are using drug products
or therapies that contain certain sugars other than glucose.
*GDH-PQQ stands for glucose dehydrogenase pyrroloquinoline quinone,

Issue
• Diabetic patients who receive drug products or therapies containing certain sugars other
than glucose could experience serious, although rare, injuries if they use blood glucose
meters with a particular type of test-strip technology. Strips that use this technology,
known as GDH-PQQ, will react with certain non-glucose sugars, including maltose,
galactose and xylose, and produce a falsely high (elevated) result. If a diabetic patient
then takes too much insulin because of this falsely high result, it could lead to abnormally
low blood sugar (hypoglycemia), coma, or even death.

Certain patients may be more likely to be using drug products or therapies that contain
other sugars, including those who:
• are on peritoneal dialysis
• have recently had surgery

Glucose test strips other than the GDH-PQQ type are not affected by this
problem, and can be used by patients taking drug products or therapies that contain
non-glucose sugars".

To read the complete notice, go to:
http://www.fda.gov/MedicalDevices/Safety/AlertsandNotices/PatientAlerts/ucm177189
.htm